This is the first edition printed in England of Jean Calvin’s Institutes in the original Latin. In its earliest recension, the Institutes were published in Basel in 1536; the first English-languge edition was printed in London in 1561. Our copy has been copiously annotated by an anonymous sixteenth-century reader. Sixteenth- and seventeenth-century books with contemporary reader notes are by virtue of our online catalog easily retrievable. The Newberry has a number of sixteenth-century editions of Calvin’s Institutes with similar annotations.